The paper explores anti-corruption (AC) institutional framework in Serbia from 2000 to 2012 in the following way. Firstly, the AC laws, agencies and state institutions are mapped. Then, the main driver of the institutional change was identified. Lastly, the AC institutional organization as a whole is analyzed. The research findings suggest that the anti-corruption institutions in Serbia developed through the process of institutional layering; they were externally driven in most cases (by the EU and international AC initiatives); and, the overall organization of the AC institutions is a hybrid structure of the three models existing worldwide.